As filed with the Securities and Exchange Commission on August 15, 2001.

                                                      Registration No. 333-_____
--------------------------------------------------------------------------------

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                   Form S-8

                            REGISTRATION STATEMENT
                                     Under
                          THE SECURITIES ACT OF 1933

                             INCYTE GENOMICS, INC.
                         ----------------------------
            (Exact name of registrant as specified in its charter)


                                                      
                    Delaware                                         94-3136539
       ----------------------------------               ----------------------------------
         (State or other jurisdiction of                          (I.R.S. Employer
          Incorporation or organization)                         Identification No.)

                3160 Porter Drive
              Palo Alto, California                                    94304
     ----------------------------------------           ----------------------------------
     (Address of Principal Executive Offices)                        (Zip Code)

                               1991 STOCK PLAN OF INCYTE GENOMICS, INC.
                               ----------------------------------------
                                      (Full title of the plan)

                  ROY A. WHITFIELD                                     Copy to:
              Chief Executive Officer                            STANTON D. WONG, ESQ.
               Incyte Genomics, Inc.                            Pillsbury Winthrop LLP
                 3160 Porter Drive                                  P.O. Box 7880
            Palo Alto, California 94304                         San Francisco, CA 94120
                  (415) 855-0555                                    (415) 983-1000
---------------------------------------------------          ------------------------------
       (Name, address and telephone number,
    including area code, of agent for service)

                        CALCULATION OF REGISTRATION FEE




            Title of                       Amount              Proposed Maximum        Proposed           Amount of
          Securities To                     To Be               Offering Price     Maximum Aggregate     Registration
          Be Registered                 Registered(1)            per Share(2)      Offering Price(2)         Fee
---------------------------------------------------------------------------------------------------------------------
                                                                                             
Common Stock, $.001 par value(3)      2,500,000 shares             $17.10             $42,750,000          $10,688
---------------------------------------------------------------------------------------------------------------------


(1)  Calculated pursuant to General Instruction E to Form S-8.

(2)  Estimated solely for the purpose of calculating the registration fee
     pursuant to Rule 457(h)(1), based upon the average of the high and low
     sales prices of the Company's Common Stock on the Nasdaq National Market on
     August 13, 2001.

(3)  Associated with the Common Stock are Series A Participating Preferred Stock
     Purchase Rights that will not be exercisable or evidenced separately from
     the Common Stock prior to the occurrence of certain events.

                               _________________

     The Registration Statement shall become effective upon filing in accordance
with Rule 462 under the Securities Act of 1933.


                         INFORMATION REQUIRED PURSUANT
                         -----------------------------
                      TO GENERAL INSTRUCTION E TO FORM S-8
                      ------------------------------------


General Instruction E Information

     This Registration Statement is being filed for the purpose of increasing
the number of securities of the same class as other securities for which a
Registration Statement of the Registrant on Form S-8 relating to the same
employee benefit plan is effective.

     Registrant's Form S-8 Registration Statements filed with the Securities and
Exchange Commission on October 3, 2000 (File No. 333-47178), July 20, 1999 (File
No. 333-83291), September 9, 1998 (File No. 333-63069), July 16, 1997 (File No.
333-31413), October 4, 1996 (File No. 333-13449), June 20, 1995 (File No. 33-
93666) and on March 10, 1994 (File No. 33-76344) are hereby incorporated by
reference.

                                    Part II

Incorporation of Documents by Reference

     The following documents previously filed by Registrant with the Commission
are hereby incorporated by reference in this Registration Statement:

     (1) Registrant's Annual Report on Form 10-K (File No. 0-27488) for the
fiscal year ended December 31, 2000;

     (2) Registrant's Quarterly Reports on Form 10-Q (File No. 0-27488) for the
quarters ended March 31, and June 30, 2001;

     (3) Registrant's Current Report on Form 8-K filed on January 10, 2001, as
amended by Form 8-K/A filed on February 5, 2001, and Current Reports on Form 8-K
filed on February 13, and February 23, 2001 (File No. 0-27488);

     (4) The description of the Common Stock contained in Registrant's
Registration Statement on Form 8-A filed January 5, 1996 (File No. 0-27488); and

     (5) The description of the Series A Participating Preferred Stock Purchase
Rights contained in Registrant's Registration Statement on Form 8-A Filed
September 30, 1998 (File No. 0-27488).

     In addition, all documents subsequently filed by Registrant pursuant to
Section 13(a), 13(c), 14 or 15(d) of the Exchange Act of 1934 prior to the
filing of a post-effective amendment which indicates that all securities offered
have been sold or which deregisters all securities then remaining unsold, shall
be deemed to be incorporated by reference in this Registration Statement and to
be a part hereof from the date of filing of such documents.


                                    EXHIBITS
                                    --------


Exhibit
 Number    Exhibit
-------    -------
        
   5.1     Opinion of Pillsbury Winthrop LLP.

  23.1     Consent of Ernst & Young LLP, Independent Auditors.

  23.2     Consent of PricewaterhouseCoopers LLP, Independent Accountants.

  23.3     Consent of PricewaterhouseCoopers LLP, Independent Accountants.

  23.4     Consent of Pillsbury Winthrop LLP (included in Exhibit 5.1).

  99.1     1991 Stock Plan of Incyte Genomics, Inc., as amended and restated
           (incorporated by reference to Exhibit 10.1 to the Company's Quarterly
           Report on Form 10-Q for the quarter ended March 31, 2001).


                                      -1-


                                   SIGNATURES
                                   ----------

   Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8, and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Palo Alto, State of California, on August 14, 2001.

                             INCYTE GENOMICS, INC.

                             By       /s/ ROY A. WHITFIELD
                                --------------------------------
                                       Roy A. Whitfield
                                    Chief Executive Officer
                                 (Principal Executive Officer)

                               POWER OF ATTORNEY
                               -----------------

     KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below constitutes and appoints Roy A. Whitfield and John M. Vuko, and each of
them, his true and lawful attorneys-in-fact and agents, each with full power of
substitution and resubstitution, for him and in his name, place and stead, in
any and all capacities, to sign any and all amendments, including post-effective
amendments, to this Registration Statement, and to file the same, with exhibits
thereto and other documents in connection therewith, with the Securities and
Exchange Commission granting unto said attorneys-in-fact and agents, and each of
them, full power and authority to do and perform each and every act and thing
requisite and necessary to be done, as fully to all intents and purposes as he
might or could do in person, hereby ratifying and confirming all that said
attorneys-in-fact and agents, or his substitute or substitutes, may do or cause
to be done by virtue hereof.

     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the date indicated:




                Signature                                    Title                              Date
                ---------                                    -----                              ----
                                                                                    

           /s/ ROY A. WHITFIELD            Chief Executive Officer (Principal             August 14, 2001
-----------------------------------------  Executive Officer) and Director
             Roy A. Whitfield

           /s/ JOHN M. VUKO                Chief Financial Officer (Principal             August 13, 2001
-----------------------------------------  Financial Officer)
             John M. Vuko

           /s/ TIMOTHY HENN                Controller (Principal Accounting Officer)      August 14, 2001
-----------------------------------------
             Timothy Henn

       /s/ JEFFREY J. COLLINSON            Director                                       August 14, 2001
-----------------------------------------
         Jeffrey J. Collinson


                                      -2-




                Signature                                    Title                              Date
                ---------                                    -----                              ----
                                                                                    
         /s/ RANDAL W. SCOTT               Chairman of the Board                          August 13, 2001
-----------------------------------------
          Randal W. Scott

         /s/ BARRY M. BLOOM                Director                                       August 13, 2001
-----------------------------------------
           Barry M. Bloom

       /s/ FREDERICK B. CRAVES             Director                                       August 10, 2001
-----------------------------------------
         Frederick B. Craves

           /s/ JON S. SAXE                 Director                                       August 13, 2001
-----------------------------------------
            Jon S. Saxe

          /s/ BARRY M. ARIKO               Director                                       August 14, 2001
-----------------------------------------
           Barry M. Ariko


                                      -3-


                               INDEX TO EXHIBITS
                               -----------------




 Exhibit
  Number    Exhibit
 -------    -------
         
   5.1      Opinion of Pillsbury Winthrop LLP.

  23.1      Consent of Ernst & Young LLP, Independent Auditors.

  23.2      Consent of PricewaterhouseCoopers LLP, Independent Accountants.

  23.3      Consent of PricewaterhouseCoopers LLP, Independent Accountants.

  23.4      Consent of Pillsbury Winthrop LLP (included in Exhibit 5.1).

  99.1      1991 Stock Plan of Incyte Genomics, Inc., as amended and restated
            (incorporated by reference to Exhibit 10.1 to the Company's
            Quarterly Report on Form 10-Q for the quarter ended March 31, 2001).


                                      -4-