SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                 SCHEDULE 13D/A
                                 (RULE 13d-102)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
            TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                  RULE 13d-2(a)

                               (Amendment No. 1)*

                                  SOLEXA, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   83420X10 5
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                   James Abell
                        c/o Abingworth Management Limited
                                 Princess House
                                38 Jermyn Street
                            London, England SW1Y 6DN
                              (+44 (0)20 7534 1500)
--------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                December 1, 2006
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of This Statement)

            If the filing person has previously filed a statement on Schedule
13G to report the acquisition that is the subject of this Schedule 13D/A, and is
filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the
following box |_|.

          Note: Schedules filed in paper format shall include a signed original
and five copies of the schedule, including all exhibits. See Rule 13d-7 for
other parties to whom copies are to be sent.

         *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

         The information required on the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



  ==============================================================================
1   NAME OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY)
    Abingworth Management Limited
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    (a)[ ]      (b)[ ]
--------------------------------------------------------------------------------
3   SEC USE ONLY
--------------------------------------------------------------------------------
4   SOURCE OF FUNDS     AF
--------------------------------------------------------------------------------
5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
    PURSUANT TO ITEMS 2(d) or 2(e)      N/A                                [ ]
--------------------------------------------------------------------------------
6   CITIZENSHIP OR PLACE OF ORGANIZATION                        England
--------------------------------------------------------------------------------
NUMBER OF           7    SOLE VOTING POWER
SHARES                     0
BENEFICIALLY       -------------------------------------------------------------
OWNED BY            8    SHARED VOTING POWER
EACH REPORTING             3,653,695
PERSON WITH        -------------------------------------------------------------
                    9    SOLE DISPOSITIVE POWER
                           0
                   -------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER
                           3,653,695
--------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        3,653,695
--------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
     SHARES                             N/A                                [ ]
--------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 8.6%
--------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON          CO
--------------------------------------------------------------------------------




  ==============================================================================
1   NAME OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY)
    Abingworth Bioventures II SICAV
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    (a)[ ]      (b)[ ]
--------------------------------------------------------------------------------
3   SEC USE ONLY
--------------------------------------------------------------------------------
4   SOURCE OF FUNDS     OO
--------------------------------------------------------------------------------
5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
    PURSUANT TO ITEMS 2(d) or 2(e)      N/A                                [ ]
--------------------------------------------------------------------------------
6   CITIZENSHIP OR PLACE OF ORGANIZATION                        Luxembourg
--------------------------------------------------------------------------------
NUMBER OF           7    SOLE VOTING POWER
SHARES                     0
BENEFICIALLY       -------------------------------------------------------------
OWNED BY            8    SHARED VOTING POWER
EACH REPORTING             3,238,300
PERSON WITH        -------------------------------------------------------------
                    9    SOLE DISPOSITIVE POWER
                           0
                   -------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER
                           3,238,300
--------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        3,238,300
--------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
     SHARES                             N/A                                [ ]
--------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 7.7%
--------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON          CO
--------------------------------------------------------------------------------


                                    3 of 17


  ==============================================================================
1   NAME OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY)
    Abingworth Bioventures II A L.P.
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    (a)[ ]      (b)[ ]
--------------------------------------------------------------------------------
3   SEC USE ONLY
--------------------------------------------------------------------------------
4   SOURCE OF FUNDS     OO
--------------------------------------------------------------------------------
5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
    PURSUANT TO ITEMS 2(d) or 2(e)      N/A                                [ ]
--------------------------------------------------------------------------------
6   CITIZENSHIP OR PLACE OF ORGANIZATION                        Luxembourg
--------------------------------------------------------------------------------
NUMBER OF           7    SOLE VOTING POWER
SHARES                     0
BENEFICIALLY       -------------------------------------------------------------
OWNED BY            8    SHARED VOTING POWER
EACH REPORTING             3,238,300
PERSON WITH        -------------------------------------------------------------
                    9    SOLE DISPOSITIVE POWER
                           0
                   -------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER
                           3,238,300
--------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        3,238,300
--------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
     SHARES                             N/A                                [ ]
--------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 7.7%
--------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON          PN
--------------------------------------------------------------------------------


                                    4 of 17


  ==============================================================================
1   NAME OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY)
    Abingworth Bioventures III A L.P.
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    (a)[ ]      (b)[ ]
--------------------------------------------------------------------------------
3   SEC USE ONLY
--------------------------------------------------------------------------------
4   SOURCE OF FUNDS     OO
--------------------------------------------------------------------------------
5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
    PURSUANT TO ITEMS 2(d) or 2(e)      N/A                                [ ]
--------------------------------------------------------------------------------
6   CITIZENSHIP OR PLACE OF ORGANIZATION                        England
--------------------------------------------------------------------------------
NUMBER OF           7    SOLE VOTING POWER
SHARES                     0
BENEFICIALLY       -------------------------------------------------------------
OWNED BY            8    SHARED VOTING POWER
EACH REPORTING             3,238,300
PERSON WITH        -------------------------------------------------------------
                    9    SOLE DISPOSITIVE POWER
                           0
                   -------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER
                           3,238,300
--------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        3,238,300
--------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
     SHARES                             N/A                                [ ]
--------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 7.7%
--------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON          PN
--------------------------------------------------------------------------------


                                    5 of 17


  ==============================================================================
1   NAME OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY)
    Abingworth Bioventures III B L.P.
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    (a)[ ]      (b)[ ]
--------------------------------------------------------------------------------
3   SEC USE ONLY
--------------------------------------------------------------------------------
4   SOURCE OF FUNDS     OO
--------------------------------------------------------------------------------
5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
    PURSUANT TO ITEMS 2(d) or 2(e)      N/A                                [ ]
--------------------------------------------------------------------------------
6   CITIZENSHIP OR PLACE OF ORGANIZATION                        England
--------------------------------------------------------------------------------
NUMBER OF           7    SOLE VOTING POWER
SHARES                     0
BENEFICIALLY       -------------------------------------------------------------
OWNED BY            8    SHARED VOTING POWER
EACH REPORTING             3,238,300
PERSON WITH        -------------------------------------------------------------
                    9    SOLE DISPOSITIVE POWER
                           0
                   -------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER
                           3,238,300
--------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        3,238,300
--------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
     SHARES                             N/A                                [ ]
--------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 7.7%
--------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON          PN
--------------------------------------------------------------------------------


                                    6 of 17


  ==============================================================================
1   NAME OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY)
    Abingworth Bioventures III C L.P.
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    (a)[ ]      (b)[ ]
--------------------------------------------------------------------------------
3   SEC USE ONLY
--------------------------------------------------------------------------------
4   SOURCE OF FUNDS     OO
--------------------------------------------------------------------------------
5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
    PURSUANT TO ITEMS 2(d) or 2(e)      N/A                                [ ]
--------------------------------------------------------------------------------
6   CITIZENSHIP OR PLACE OF ORGANIZATION                        England
--------------------------------------------------------------------------------
NUMBER OF           7    SOLE VOTING POWER
SHARES                     0
BENEFICIALLY       -------------------------------------------------------------
OWNED BY            8    SHARED VOTING POWER
EACH REPORTING             3,238,300
PERSON WITH        -------------------------------------------------------------
                    9    SOLE DISPOSITIVE POWER
                           0
                   -------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER
                           3,238,300
--------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        3,238,300
--------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
     SHARES                             N/A                                [ ]
--------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 7.7%
--------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON          PN
--------------------------------------------------------------------------------


                                    7 of 17


  ==============================================================================
1   NAME OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY)
    Abingworth Bioventures III Executives L.P.
--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    (a)[ ]      (b)[ ]
--------------------------------------------------------------------------------
3   SEC USE ONLY
--------------------------------------------------------------------------------
4   SOURCE OF FUNDS     OO
--------------------------------------------------------------------------------
5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
    PURSUANT TO ITEMS 2(d) or 2(e)      N/A                                [ ]
--------------------------------------------------------------------------------
6   CITIZENSHIP OR PLACE OF ORGANIZATION                        England
--------------------------------------------------------------------------------
NUMBER OF           7    SOLE VOTING POWER
SHARES                     0
BENEFICIALLY       -------------------------------------------------------------
OWNED BY            8    SHARED VOTING POWER
EACH REPORTING             3,238,300
PERSON WITH        -------------------------------------------------------------
                    9    SOLE DISPOSITIVE POWER
                           0
                   -------------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER
                           3,238,300
--------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        3,238,300
--------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
     SHARES                             N/A                                [ ]
--------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 7.7%
--------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON          PN
--------------------------------------------------------------------------------


                                    8 of 17


                                 SCHEDULE 13D/A

This Schedule 13D/A (the "Amendment") amends the Schedule 13D, filed by the
Reporting Persons (as defined below) on February 13, 2006.

ITEM 1.  SECURITY AND ISSUER.

      (a) The class of equity securities to which this statement relates is
common stock, par value $0.01 per share (the "Common Stock"), of Solexa, Inc., a
Delaware corporation (the "Issuer" or "SLXA").

      (b) The principal executive offices of the Issuer are located at 25861
Industrial Blvd., Hayward, California, 94545.

ITEM 2.  IDENTITY AND BACKGROUND.

      (a) This Statement is being filed on behalf of: (i) Abingworth Management
Limited ("Abingworth Management"), (ii) Abingworth Bioventures II SICAV ("ABV II
SICAV"), (iii) Abingworth Bioventures II A L.P. ("ABV II A"), (iv) Abingworth
Bioventures III A L.P. ("ABV III A"), (v) Abingworth Bioventures III B L.P.
("ABV III B"), (vi) Abingworth Bioventures III C L.P. ("ABV III C"), and (vii)
Abingworth Bioventures III Executives L.P. ("ABV III Executives", together with
ABV II SICAV, ABV II A, ABV III A, ABV III B and ABV III C the "Funds").

      The Funds share a manager, Abingworth Management, and are affiliated
funds, and, on this basis, may be deemed to beneficially own the shares held by
one another. Each of the Funds disclaims beneficial ownership of such shares of
Common Stock except for the shares, if any, such Fund holds of record.
Abingworth Management may be deemed to beneficially own the shares of Common
Stock held of record by the Funds and Abingworth Bioequities Master Fund Limited
("ABE") for which Abingworth Management is the manager. The persons named in
this paragraph (other than ABE) are referred to individually herein as a
"Reporting Person" and collectively as the "Reporting Persons."

      (b) The address of the principal business office of Abingworth Management,
ABV II SICAV, ABV II A, ABV III A, ABV III B, ABV III C, and ABV III Executives
is c/o Abingworth Management Limited, Princess House, 38 Jermyn Street, London,
England SW1Y 6DN.

      (c) The principal business of the Funds is to invest in and assist
growth-oriented businesses in the life science and biomedical industries. The
principal business of Abingworth Management is to manage the affairs of the
Funds.

      (d) During the five years prior to the date hereof, none of the Reporting
Persons has been convicted in a criminal proceeding.

      (e) During the five years prior to the date hereof, none of the Reporting
Persons has been a party to a civil proceeding of a judicial or administrative
body of competent jurisdiction ending in a judgment, decree or final order
enjoining future violations of, or prohibiting or mandating activities subject
to, Federal or State securities laws or finding any violation with respect to
such laws.

      (f) Abingworth Management is a corporation organized under the laws of
England. ABV II SICAV is a corporation organized under the laws of Luxembourg.



                                    9 of 17


Each of ABV II A, ABV III A, ABV III B, and ABV III C is a  limited  partnership
organized under the laws of England. ABV III Executives is a limited partnership
organized under the laws of the State of Delaware.

ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

      Not applicable.

ITEM 4.  PURPOSE OF TRANSACTION.

      Depending on market conditions and the market price of the Issuer's Common
Stock, the Reporting Persons may dispose of additional shares of the Issuer.
Except as set forth above, none of the Reporting Persons has any present plans
which relate to or would result in:

      (a) The acquisition by any person of additional securities of the Issuer,
or the disposition of securities of the Issuer;

      (b) An extraordinary corporate transaction, such as a merger,
reorganization or liquidation, involving the Issuer or any of its subsidiaries;

      (c) A sale or transfer of a material amount of assets of the Issuer or any
of its subsidiaries;

      (d) Any change in the present board of directors or management of the
Issuer, including any plans or proposals to change the number or term of
directors or to fill any existing vacancies on the board;

      (e) Any material change in the present capitalization or dividend policy
of the Issuer;

      (f) any other material change in the Issuer's business or corporate
structure;

      (g) Changes in the Issuer's charter, bylaws or instruments corresponding
thereto or other actions which may impede the acquisition of control of the
Issuer by any person;

      (h) Causing a class of securities of the Issuer to be delisted from a
national securities exchange or to cease to be authorized to be quoted in an
inter-dealer quotation system of a registered national securities association;

      (i) A class of equity securities of the Issuer becoming eligible for
termination of registration pursuant to Section 12(g)(4) of the Securities
Exchange Act of 1934; or

      (j) Any action similar to any of those enumerated above.

ITEM 5.  INTEREST IN SECURITIES OF ISSUER.

      (a)   As of the filing of this Amendment, (i) ABV II SICAV is the owner of
record of 1,203,341 shares of the Common Stock of the Issuer, (ii) ABV II A is
the owner of record of 325,618 shares of the Common Stock of the Issuer and
immediately exercisable warrants to purchase 125,000 shares of Common Stock,
(iii) ABV III A is the owner of record of 649,852 shares of the Common Stock of
the Issuer and immediately exercisable warrants to purchase 145,489 shares of
Common Stock, (iv) ABV III B is the owner of record of 396,687 shares of the
Common Stock of the Issuer and immediately exercisable warrants to purchase
88,812 shares of Common Stock, (v) ABV III C is the owner of record of 237,621



                                    10 of 17


shares of the Common Stock of the Issuer and immediately exercisable warrants to
purchase 53,200 shares of Common Stock, (vi) ABV III Executives is the owner of
record of 10,360 shares of the Common Stock of the Issuer and immediately
exercisable warrants to purchase 2,319 shares of Common Stock and (vii) ABE is
the owner of record of 307,700 shares of the Common Stock of the Issuer and
immediately exercisable warrants to purchase 107,695 shares of Common Stock. The
Funds, collectively, may be deemed to beneficially own 3,238,300 shares of
Common Stock (which includes the immediately exercisable warrants to purchase
414,820 shares of Common Stock held by the Funds), comprising 7.7% of the
outstanding Common Stock of the Issuer. Abingworth Management, as the manager of
each of the Funds and ABE, may be deemed to beneficially own 3,653,695 shares of
Common Stock (which includes the immediately exercisable warrants to purchase
414,820 shares of Common Stock held by the Funds and the immediately exercisable
warrants to purchase 107,695 shares of Common Stock held by ABE), comprising
8.6% of the outstanding Common Stock of the Issuer. These numbers are based on a
total of 41,819,832 shares of Common Stock of the Issuer outstanding as of
December 6, 2006, as reported by the Issuer in a communication to the Reporting
Persons.

      (b)   Number of shares as to which each person named in paragraph (a)
above has:

            (i)   sole power to vote or to direct the vote: see line 7 of cover
                  sheets.

            (ii)  shared power to vote or to direct the vote: see line 8 of
                  cover sheets.

            (iii) sole power to dispose or to direct the disposition: see line 9
                  of cover sheets.

            (iv)  shared power to dispose or to direct the disposition: see line
                  10 of cover sheets.

      (c)   Between November 24, 2006 and December 4, 2006,

            (i)   ABV II SICAV sold an aggregate of 213,097 shares of Common
                  Stock on the open market for an aggregate consideration of
                  $2,603,847 (10,716 shares were sold on November 24, 2006;
                  46,456 shares were sold on November 28, 2006; 42,619 shares
                  were sold on November 29, 2006; 42,619 shares were sold on
                  November 30, 2006; 42,619 shares were sold on December 1,
                  2006; and 28,068 shares were sold on December 4, 2006);

            (ii)  ABV II A sold an aggregate of 57,661 shares of Common Stock on
                  the open market for an aggregate consideration of $704,552
                  (2,900 shares were sold on November 24, 2006; 12,570 shares
                  were sold on November 28, 2006; 11,532 shares were sold on
                  November 29, 2006; 11,532 shares were sold on November 30,
                  2006; 11,532 shares were sold on December 1, 2006; and 7,595
                  shares were sold on December 4, 2006);

            (iii) ABV III A sold an aggregate of 115,079 shares of Common Stock
                  on the open market for an aggregate consideration of
                  $1,478,834.56 (5,787 shares were sold on November 24, 2006;
                  25,087 shares were sold on November 28, 2006; 23,016 shares
                  were sold on November 29, 2006; 23,016 shares were sold on
                  November 30, 2006; 23,016 shares were sold on December 1,
                  2006; and 15,157 shares were sold on December 4, 2006);


                                    11 of 17


            (iv)  ABV III B sold an aggregate of 70,249 shares of Common Stock
                  on the open market for an aggregate consideration of $858,389
                  (3,532 shares were sold on November 24, 2006; 15,314 shares
                  were sold on November 28, 2006; 14,050 shares were sold on
                  November 29, 2006; 14,050 shares were sold on November 30,
                  2006; 14,050 shares were sold on December 1, 2006; and 9,253
                  shares were sold on December 4, 2006);

            (v)   ABV III C sold an aggregate of 42,079 shares of Common Stock
                  on the open market for an aggregate consideration of
                  $514,166.28 (2,116 shares were sold on November 24, 2006;
                  9,173 shares were sold on November 28, 2006; 8,416 shares were
                  sold on November 29, 2006; 8,416 shares were sold on November
                  30, 2006; 8,416 shares were sold on December 1, 2006; and
                  5,542 shares were sold on December 4, 2006;

            (vi)  ABV III Executives sold an aggregate of 1,835 shares of Common
                  Stock on the open market for an aggregate consideration of
                  $62,889.91 (92 shares were sold on November 24, 2006; 400
                  shares were sold on November 28, 2006; 367 shares were sold on
                  November 29, 2006; 367 shares were sold on November 30, 2006;
                  367 shares were sold on December 1, 2006; and 242 shares were
                  sold on December 4, 2006.

            All of the Reporting Persons sold the above shares on the open
            market. The average price per share for shares of Common Stock sold
            by each of the above Reporting Persons on the dates specified above
            was as follows: $12.56 on November 24, 2006; $12.15 on November 28,
            2006; $12.25 on November 29, 2006; $12.29 on November 30, 2006;
            $12.07 on December 1, 2006; and $12.22 on December 4, 2006.

      (d)   No other person is known to have the right to receive or the power
to direct the receipt of dividends from, or any proceeds from the sale of the
shares beneficially owned by any of the Reporting Persons.

      (e)   Not applicable.

ITEM 6. CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT TO
SECURITIES OF THE ISSUER.

      Not applicable.

ITEM 7.  MATERIAL TO BE FILED AS EXHIBITS.

      A.    Agreement regarding filing of joint Schedule 13D/A.


                                    12 of 17


                                   SIGNATURES

      After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated: December 15, 2006

                              ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director

                              ABINGWORTH BIOVENTURES II SICVA IN LIQUIDATION

                              By: /s/ Genevieve Blauen
                                 ---------------------------------------
                              Name:  Genevieve Blauen
                              Title:  Liquidator

                              By: /s/ Fernand Heim
                                 ---------------------------------------
                              Name:  Fernand Heim
                              Title:  Mandatory

                              ABINGWORTH BIOVENTURES II A L.P.
                              BY ITS MANAGER, ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director

                              ABINGWORTH BIOVENTURES III A L.P.
                              BY ITS MANAGER, ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director

                              ABINGWORTH BIOVENTURES III B L.P.
                              BY ITS MANAGER, ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell


                                    13 of 17


                              Title:  Executive Director

                              ABINGWORTH BIOVENTURES III C L.P.
                              BY ITS MANAGER, ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director

                              ABINGWORTH BIOVENTURES III EXECUTIVES L.P.
                              BY ITS MANAGER, ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director


                                    14 of 17


                                  EXHIBIT INDEX

      A.    Agreement regarding filing of joint Schedule 13D/A.


                                    15 of 17


                                    Exhibit A

                            JOINT FILING UNDERTAKING

         Pursuant to Rule 13d-1(k)(1) promulgated under the Securities Exchange
Act of 1934, as amended, each of the undersigned agree that the Schedule 13D/A,
and any amendments thereto, filed with respect to the beneficial ownership by
the undersigned of the equity securities of Solexa, Inc., is being filed on
behalf of each of the undersigned.

Dated: December 15, 2006

                              ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director

                              ABINGWORTH BIOVENTURES II SICVA IN LIQUIDATION

                              By: /s/ Genevieve Blauen
                                 ---------------------------------------
                              Name:  Genevieve Blauen
                              Title:  Liquidator

                              By: /s/ Fernand Heim
                                 ---------------------------------------
                              Name:  Fernand Heim
                              Title:  Mandatory

                              ABINGWORTH BIOVENTURES II A L.P.
                              BY ITS MANAGER, ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director

                              ABINGWORTH BIOVENTURES III A L.P.
                              BY ITS MANAGER, ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director


                                    16 of 17


                              ABINGWORTH BIOVENTURES III B L.P.
                              BY ITS MANAGER, ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director

                              ABINGWORTH BIOVENTURES III C L.P.
                              BY ITS MANAGER, ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director

                              ABINGWORTH BIOVENTURES III EXECUTIVES L.P.
                              BY ITS MANAGER, ABINGWORTH MANAGEMENT LIMITED

                              By: /s/ James Abell
                                 ---------------------------------------
                              Name:  James Abell
                              Title:  Executive Director


                                    17 of 17