UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934

                                (Amendment No. 2)

                                  ANORMED, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                      Common Stock, no par value per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    035910108
     ----------------------------------------------------------------------
                                 (CUSIP Number)

                                    Leo Kirby
                         667 Madison Avenue, 19th Floor
                               New York, NY 10021
                                 (212) 521-2418
--------------------------------------------------------------------------------
 (Name, Address and Telephone Number of Person Authorized to Receive Notices 
                              and Communications)

                                January 11, 2006
     ----------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Rule  13d-1(e),  13d-1(f) or 13d-1(g),  check the following
box.

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 (the "Act") or otherwise  subject to the liabilities of that section of the
Act but shall be subject to all other  provisions of the Act  (however,  see the
Notes).

                               Page 1 of 10 Pages


                                  SCHEDULE 13D


CUSIP No. 035910108                                           Page 2 of 10 Pages

--------- ----------------------------------------------------------------------
   1      NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

                   Julian C. Baker
--------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                      
          (See Instructions)                                         (a) |_|    
                                                                     (b) |X|    
--------- ----------------------------------------------------------------------
   3      SEC USE ONLY
--------- ----------------------------------------------------------------------
          SOURCE OF FUNDS (See Instructions)
   4
                   WC
--------- ----------------------------------------------------------------------
   5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT 
          TO ITEMS 2(d) OR 2(e)                                      (a) |_|
--------- ----------------------------------------------------------------------
   6      CITIZENSHIP OR PLACE OF ORGANIZATION

          United States
--------- ----------------------------------------------------------------------
       NUMBER OF            7     SOLE VOTING POWER
         SHARES
      BENEFICIALLY                         0
        OWNED BY
          EACH
       REPORTING
         PERSON
          WITH
------------------------- ------- ----------------------------------------------
                            8     SHARED VOTING POWER

                                           9,411,500
------------------------- ------- ----------------------------------------------
                                  SOLE DISPOSITIVE POWER
                            9
                                           0
------------------------- ------- ----------------------------------------------
                                  SHARED DISPOSITIVE POWER
                            10
                                           9,411,500
------------------------- ------- ----------------------------------------------
   11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                   9,411,500
--------- ----------------------------------------------------------------------
   12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES 
          (See Instructions)
--------- ----------------------------------------------------------------------
   13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                   23.3%
--------- ----------------------------------------------------------------------
          TYPE OF REPORTING PERSON (See Instructions)
   14
                   IN
--------- ----------------------------------------------------------------------



                                  SCHEDULE 13D


CUSIP No. 035910108                                           Page 3 of 10 Pages

--------- ----------------------------------------------------------------------
   1      NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

                   Felix J. Baker
--------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP 
          (See Instructions)                                         (a) |_|
                                                                     (b) |X|
--------- ----------------------------------------------------------------------
   3      SEC USE ONLY
--------- ----------------------------------------------------------------------
          SOURCE OF FUNDS (See Instructions)
   4
                   WC
--------- ----------------------------------------------------------------------
   5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT 
          TO ITEMS 2(d) OR 2(e)                                      |_|
--------- ----------------------------------------------------------------------
   6      CITIZENSHIP OR PLACE OF ORGANIZATION

          United States
--------- ----------------------------------------------------------------------
       NUMBER OF            7     SOLE VOTING POWER
         SHARES
      BENEFICIALLY                         25,000
        OWNED BY
          EACH
       REPORTING
         PERSON
          WITH
------------------------- ------- ----------------------------------------------
                            8     SHARED VOTING POWER

                                           9,411,500
------------------------- ------- ----------------------------------------------
                                  SOLE DISPOSITIVE POWER
                            9
                                           25,000
------------------------- ------- ----------------------------------------------
                                  SHARED DISPOSITIVE POWER
                            10
                                           9,411,500
------------------------- ------- ----------------------------------------------
   11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                   9,436,500
--------- ----------------------------------------------------------------------
   12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES 
          (See Instructions)
--------- ----------------------------------------------------------------------
   13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                   23.3%
--------- ----------------------------------------------------------------------
          TYPE OF REPORTING PERSON (See Instructions)
   14
                   IN
--------- ----------------------------------------------------------------------





      This Amendment No. 2 to Schedule 13D is being filed by Julian C. Baker and
Felix J. Baker (the  "Reporting  Persons") to amend and supplement the statement
on Schedule 13D  previously  filed by them,  as  heretofore  amended.  Except as
amended  and  supplemented  hereby,  that  statement  remains  in full force and
effect.

Item 4. Purpose of Transaction.

      Following the filing by the Reporting  Persons of their Amendment No. 1 to
their  statement on Schedule 13D, the Reporting  Persons were contacted by David
Scott,  the Chairman of the Board of the Company.  In their  discussion with Mr.
Scott,  the Reporting  Persons  suggested  that the  composition of the Board of
Directors  be  changed  so that Felix  Baker,  who is already a director  of the
Company,  would become Chairman and a majority of the members of the Board would
consist of Dr. Baker and independent nominees suggested by him.

      Subsequently, Mr. Scott sent a letter dated January 11, 2006 to Dr. Baker,
asking for further information  regarding the proposal. A copy of this letter is
attached as Exhibit 2 to this  Amendment  No. 2. On January 13, 2006,  Dr. Baker
replied  to Mr.  Scott  by  enclosing  a formal  request  for the  calling  of a
shareholders'  meeting to remove the current  directors and elect a new Board. A
copy of this letter is attached as Exhibit 3 to this  Amendment No. 2. As of the
time of filing  this  Amendment  No. 2, no  response  to the letter  attached as
Exhibit 3 has been received.

      The Reporting Persons intend to continue to evaluate their alternatives as
circumstances develop.






Item 5. Interest in Securities of the Issuer.

            Because  of  certain  business  relationships  among  the  Reporting
Persons,  they are filing as if they constitute a group solely for informational
purposes.  However,  the filing of this  statement  is not an  admission  by any
Reporting  Person that such Reporting  Person and any other Reporting  Person or
Reporting  Persons  constitute a "group" for purposes of Section 13(d)(3) of the
Securities  Exchange Act of 1934,  as amended,  or Rule 13d-5  thereunder.  Each
Reporting  Person disclaims  beneficial  ownership of any shares of Common Stock
owned by any other  Reporting  Person,  except  to the  extent  that  beneficial
ownership is expressly reported herein.

            Set forth in the table  below is the  aggregate  number of shares of
Common Stock owned,  including  shares that may be acquired upon the exercise of
options  by each of the  following  on  January  13,  2006,  together  with  the
percentage of outstanding shares of Common Stock that such ownership  represents
based upon 40,501,692 shares  outstanding as reported on the Company's  December
8, 2005 press release.

                               Page 4 of 10 Pages


                                                       Percent of Class 
                     Name           Number of Shares     Outstanding    
                     ----           ----------------     -----------    
                                                       
Baker Bros. Investments, L.P.             330,058            0.8%
Baker Bros. Investments II, L.P.          351,749            0.9%
Baker Biotech Fund I, L.P.              3,604,520            8.9%
Baker Biotech Fund II, L.P.             3,308,484            8.2%
Baker Biotech Fund II (Z), L.P.           446,129            1.1%
Baker Biotech Fund III, L.P.            1,065,455            2.6%
Baker Biotech Fund III (Z), L.P.          193,791            0.5%
14159, L.P.                                83,137            0.2%
Baker / Tisch Investments, L.P.            28,177            0.1%
Felix J. Baker                             25,000            0.0%
                                        ---------            ----
Total                                   9,436,500           23.3%


            By  virtue of their  ownership  of  entities  that have the power to
control the investment decisions of the limited partnerships listed in the table
above,  Julian C. Baker and Felix J.  Baker may each be deemed to be  beneficial
owners of shares  owned by such  entities and may be deemed to have shared power
to vote or  direct  the  vote of and  shared  power to  dispose  or  direct  the
disposition of such securities.


                               Page 5 of 10 Pages


            In  addition  to the  December  8, 2005  purchases  of Common  Stock
reported on the reporting persons' previously filed Schedule 13D Amendment No.1,
the issuer granted 5,000 stock options to Felix J. Baker in connection  with his
service as a director of the issuer on December 15, 2005. Each option represents
the right to purchase  one share of Common  Stock at an exercise  price of $4.42
CAD.



Item 7. Material To Be Filed as Exhibits.

Exhibit 1         Agreement regarding the joint filing of this statement.

Exhibit 2         Letter dated January 11, 2006 from David Scott to Felix Baker.

Exhibit 3         Letter dated January 13, 2006 from Felix Baker to David Scott.


                               Page 6 of 10 Pages


                                    SIGNATURE

            After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.

January 16, 2006

                                                     By:  /s/ Julian C. Baker   
                                                          ----------------------
                                                             Julian C. Baker

                                                     By:  /s/ Felix J. Baker    
                                                          ----------------------
                                                            Felix J. Baker

                               Page 7 of 10 Pages