Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Hoffman Michael B
2. Date of Event Requiring Statement (Month/Day/Year)
07/24/2013
3. Issuer Name and Ticker or Trading Symbol
Onconova Therapeutics, Inc. [ONTX]
(Last)
(First)
(Middle)
712 FIFTH AVENUE, 51ST FLOOR
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

NEW YORK, NY 10019
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock (1) 644,660
I
By The Michael and Jane Hoffman 2013 Descendants Trust (1)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Series B Convertible Preferred Stock   (2)   (2) Common Stock 99,350 $ (2) I By The Michael and Jane Hoffman 2013 Descendants Trust (1)
Series C Convertible Preferred Stock   (3)   (3) Common Stock 140,449 $ (3) I By The Michael and Jane Hoffman 2013 Descendants Trust (1)
Series D Convertible Preferred Stock   (4)   (4) Common Stock 355,528 $ (4) I By The Michael and Jane Hoffman 2013 Descendants Trust (1)
Series E Convertible Preferred Stock   (5)   (5) Common Stock 634,625 $ (5) I By The Michael and Jane Hoffman 2013 Descendants Trust (1)
Series F Convertible Preferred Stock   (6)   (6) Common Stock 111,227 $ (6) I By The Michael and Jane Hoffman 2013 Descendants Trust (1)
Series F Convertible Preferred Stock   (6)   (6) Common Stock 109,653 $ (6) I By The Michael and Jane Hoffman 2013 Descendants Trust (Non-GST Exempt Trust) (1)
Series G Convertible Preferred Stock   (7)   (7) Common Stock 229,825 $ (7) I By The Michael and Jane Hoffman 2013 Descendants Trust (1)
Series H Convertible Preferred Stock   (8)   (8) Common Stock 301,290 $ (8) I By The Michael and Jane Hoffman 2013 Descendants Trust (1)
Series I Convertible Preferred Stock   (9)   (9) Common Stock 1,635,514 $ (9) I By The Michael and Jane Hoffman 2013 Descendants Trust (1)
Stock Option (right to purchase) 03/31/2009 04/01/2016 Common Stock 18,754 $ 2.67 D  
Stock Option (right to purchase) 10/04/2007 10/04/2017 Common Stock 56,264 $ 6 D  
Stock Option (right to purchase) 03/17/2010 03/17/2020 Common Stock 52,513 $ 5.76 D  
Stock Option (right to purchase) 04/18/2011 04/18/2021 Common Stock 18,754 $ 6.13 D  
Stock Option (right to purchase) 12/05/2011 12/05/2021 Common Stock 18,754 $ 6.13 D  
Stock Option (right to purchase) 01/01/2013 01/02/2023 Common Stock 37,509 $ 13.28 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Hoffman Michael B
712 FIFTH AVENUE, 51ST FLOOR
NEW YORK, NY 10019
  X   X    

Signatures

/s/ Ajay Bansal, as attorney in fact 07/24/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These shares are held in a trust for the benefit of the reporting person's descendents. The reporting person's spouse is a trustee of the trust.
(2) The convertible preferred stock is convertible at any time, at the holder's election, and is automatically convertible immediately prior to the consummation of the Issuer's initial public offering on a 0.85-for-1 basis and has no expiration date.
(3) The convertible preferred stock is convertible at any time, at the holder's election, and is automatically convertible immediately prior to the consummation of the Issuer's initial public offering on a 0.75-for-1 basis and has no expiration date.
(4) The convertible preferred stock is convertible at any time, at the holder's election, and is automatically convertible immediately prior to the consummation of the Issuer's initial public offering on a 0.75-for-1 basis and has no expiration date.
(5) The convertible preferred stock is convertible at any time, at the holder's election, and is automatically convertible immediately prior to the consummation of the Issuer's initial public offering on a 0.75-for-1 basis and has no expiration date.
(6) The convertible preferred stock is convertible at any time, at the holder's election, and is automatically convertible immediately prior to the consummation of the Issuer's initial public offering on a 0.77-for-1 basis and has no expiration date.
(7) The convertible preferred stock is convertible at any time, at the holder's election, and is automatically convertible immediately prior to the consummation of the Issuer's initial public offering on a 0.75-for-1 basis and has no expiration date.
(8) The convertible preferred stock is convertible at any time, at the holder's election, and is automatically convertible immediately prior to the consummation of the Issuer's initial public offering on a 0.75-for-1 basis and has no expiration date.
(9) The convertible preferred stock is convertible at any time, at the holder's election, and is automatically convertible immediately prior to the consummation of the Issuer's initial public offering on a 0.75-for-1 basis and has no expiration date.

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