Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0104
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
  Valenzano Ken
 2. Date of Event Requiring Statement (Month/Day/Year)
05/10/2010		 3. Issuer Name and Ticker or Trading Symbol
AMICUS THERAPEUTICS INC [FOLD]
(Last)
(First)
(Middle)
6 CEDAR BROOK DRIVE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP, Pharmacology & Biology
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CRANBURY, NJ 08512		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 1,708
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Options (right to buy) 06/01/2009 06/09/2015 Common Stock 2,793 $ 0.64 D  
Stock Options (right to buy) 10/01/2009 10/20/2015 Common Stock 2,000 $ 5.33 D  
Stock Options (right to buy) 02/01/2010 02/28/2016 Common Stock 9,500 $ 5.33 D  
Stock Options (right to buy)   (1) 04/25/2017 Common Stock 13,334 $ 13.43 D  
Stock Options (right to buy)   (2) 02/05/2018 Common Stock 12,500 $ 10.21 D  
Stock Options (right to buy)   (3) 02/03/2019 Common Stock 12,000 $ 10.36 D  
Stock Options (right to buy)   (4) 11/16/2019 Common Stock 30,000 $ 4.16 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Valenzano Ken
6 CEDAR BROOK DRIVE
CRANBURY, NJ 08512		       VP, Pharmacology & Biology  

Signatures

/s/ KEN VALENZANO 05/19/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on April 25, 2008. The remaining options vest and become exercisable in a series of thirty-six equal monthly installments, beginning on May 1, 2008.
(2) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on February 5, 2009. The remaining options vest and become exercisable in a series of thirty-six equal monthly installments, beginning on March 1, 2009.
(3) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on February 3, 2010. The remaining options vest and become exercisable in a series of thirty-six equal monthly installments, beginning on March 1, 2010.
(4) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, will vest on November 16, 2010. The remaining options will vest and become exercisable in a series of thirty-six equal monthly installments, beginning on December 1, 2010.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.