FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * YANCOPOULOS GEORGE   2. Issuer Name and Ticker or Trading Symbol REGENERON PHARMACEUTICALS INC [REGN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) EVP CSO Pres Regen Res Labs (Last) (First) (Middle) 777 OLD SAW MILL RIVER ROAD 3. Date of Earliest Transaction (Month/Day/Year) 12/14/2012 (Street) TARRYTOWN, NY 10591 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12/14/2012   F(1)   38,391 D $ 179.13 1,294,650 D   Common Stock 12/17/2012   M(1)   266 A $ 109.29 1,294,916 D   Common Stock 12/17/2012   F(1)   161 D $ 179.13 1,294,755 D   Common Stock 12/17/2012   F(1)   47 D $ 179.13 1,294,708 D   Common Stock 12/17/2012   M(1)   10,103 A $ 109.29 1,304,811 D   Common Stock 12/17/2012   F(1)   6,163 D $ 179.13 1,298,648 D   Common Stock 12/17/2012   F(1)   1,814 D $ 179.13 1,296,834 D   Common Stock 12/17/2012   F(1)   230,350 D $ 179.13 1,066,484 D   Common Stock               5,534 I By 401(k) Plan

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Non-Qualified Stock Option (right to buy)

$ 21.25

12/14/2012

A

150,000

(2)

12/18/2019

Common Stock

150,000

(3)

245,295

D

Non-Qualified Stock Option (right to buy)

$ 109.29

12/17/2012

M(1)

266

08/15/2012

12/20/2012

Common Stock

266

(3)

10,103

D

Non-Qualified Stock Option (right to buy)

$ 109.29

12/17/2012

M(1)

10,103

08/15/2012

12/20/2012

Common Stock

10,103

(3)

0

D

Non-Qualified Stock Option (right to buy)

$ 179.13

12/14/2012

A

239,063

(4)

12/14/2022

Common Stock

239,063

(3)

239,063

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
YANCOPOULOS GEORGE 777 OLD SAW MILL RIVER ROAD TARRYTOWN, NY 10591	X		EVP CSO Pres Regen Res Labs

Signatures

/s/**George D. Yancopoulos		12/18/2012
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).
(2)	On December 18, 2009, the reporting person was granted an option to purchase 150,000 shares of Common Stock. The option vests, partially or in full, on December 31, 2012, based on the extent to which the company satisfies certain performance criteria during the period ending December 31, 2012. The performance criteria have been met and the option will vest as to all 150,000 shares on December 31, 2012.
(3)	Exercisable date, exercise date, exercise price, purchase price, sales price, and/or expiration date is/are not applicable in this case.
(4)	The stock option award vests in four equal annual installments, commencing one year after the date of grant.

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