Rule 13d-1(b)
|
|
Rule 13d-1(c)
|
|
X
|
Rule 13d-1(d)
|
CUSIP No. 89532E109
|
13G
|
Page 2 of 14 Pages
|
1
|
NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
HealthCare Ventures VIII, L.P.
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [X1]
|
||
3
|
SEC USE ONLY
|
||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
||
NUMBER OF
|
5
|
SOLE VOTING POWER
|
|
SHARES
BENEFICIALLY
OWNED BY
|
6
|
SHARED VOTING POWER
2,446,251
|
|
EACH
REPORTING
PERSON
|
7
|
SOLE DISPOSITIVE POWER
|
|
WITH
|
8
|
SHARED DISPOSITIVE POWER
2,446,251
|
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,446,251
|
||
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
|
||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
4.8%
|
||
12
|
TYPE OF REPORTING PERSON*
PN
|
CUSIP No. 89532E109
|
13G
|
Page 3 of 14 Pages
|
1
|
NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
HealthCare Partners VIII, L.P.
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
b) [X]
See Footnote 1
|
||
3
|
SEC USE ONLY
|
||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
||
NUMBER OF
|
5
|
SOLE VOTING POWER
|
|
SHARES
BENEFICIALLY
OWNED BY
|
6
|
SHARED VOTING POWER
2,446,251
|
|
EACH
REPORTING
PERSON
|
7
|
SOLE DISPOSITIVE POWER
|
|
WITH
|
8
|
SHARED DISPOSITIVE POWER
2,446,251
|
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,446,251
|
||
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
|
||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
4.8%
|
||
12
|
TYPE OF REPORTING PERSON*
PN
|
CUSIP No. 89532E109
|
13G
|
Page 4 of 14 Pages
|
1
|
NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
HealthCare Partners VIII, LLC
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [X]
See Footnote 1
|
||
3
|
SEC USE ONLY
|
||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
||
NUMBER OF
|
5
|
SOLE VOTING POWER
|
|
SHARES
BENEFICIALLY
OWNED BY
|
6
|
SHARED VOTING POWER
2,446,251
|
|
EACH
REPORTING
PERSON
|
7
|
SOLE DISPOSITIVE POWER
|
|
WITH
|
8
|
SHARED DISPOSITIVE POWER
2,446,251
|
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,446,251
|
||
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
|
||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
4.8%
|
||
12
|
TYPE OF REPORTING PERSON*
OO
|
CUSIP No. 89532E109
|
13G
|
Page 5 of 14 Pages
|
1
|
NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
James H. Cavanaugh, Ph.D.
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [X]
See Footnote 1
|
||
3
|
SEC USE ONLY
|
||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
||
NUMBER OF
|
5
|
SOLE VOTING POWER
|
|
SHARES
BENEFICIALLY
OWNED BY
|
6
|
SHARED VOTING POWER
2,446,251
|
|
EACH
REPORTING
PERSON
|
7
|
SOLE DISPOSITIVE POWER
|
|
WITH
|
8
|
SHARED DISPOSITIVE POWER
2,446,251
|
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,446,251
|
||
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
|
||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
4.8%
|
||
12
|
TYPE OF REPORTING PERSON*
IN
|
CUSIP No. 89532E109
|
13G
|
Page 6 of 14 Pages
|
1
|
NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
Christopher Mirabelli, Ph.D.
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [X]
See Footnote 1
|
||
3
|
SEC USE ONLY
|
||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
||
NUMBER OF
|
5
|
SOLE VOTING POWER
|
|
SHARES
BENEFICIALLY
OWNED BY
|
6
|
SHARED VOTING POWER
2,446,251
|
|
EACH
REPORTING
PERSON
|
7
|
SOLE DISPOSITIVE POWER
|
|
WITH
|
8
|
SHARED DISPOSITIVE POWER
2,446,251
|
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,446,251
|
||
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
|
||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
4.8%
|
||
12
|
TYPE OF REPORTING PERSON*
IN
|
CUSIP No. 89532E109
|
13G
|
Page 7 of 14 Pages
|
1
|
NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
Harold R. Werner
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [X]
See Footnote 1
|
||
3
|
SEC USE ONLY
|
||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
||
NUMBER OF
|
5
|
SOLE VOTING POWER
|
|
SHARES
BENEFICIALLY
OWNED BY
|
6
|
SHARED VOTING POWER
2,446,251
|
|
EACH
REPORTING
PERSON
|
7
|
SOLE DISPOSITIVE POWER
|
|
WITH
|
8
|
SHARED DISPOSITIVE POWER
2,446,251
|
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,446,251
|
||
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
|
||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
4.8%
|
||
12
|
TYPE OF REPORTING PERSON*
IN
|
CUSIP No. 89532E109
|
13G
|
Page 8 of 14 Pages
|
1
|
NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
John W. Littlechild
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [X]
See Footnote 1
|
||
3
|
SEC USE ONLY
|
||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
||
NUMBER OF
|
5
|
SOLE VOTING POWER
|
|
SHARES
BENEFICIALLY
OWNED BY
|
6
|
SHARED VOTING POWER
2,446,251
|
|
EACH
REPORTING
PERSON
|
7
|
SOLE DISPOSITIVE POWER
|
|
WITH
|
8
|
SHARED DISPOSITIVE POWER
2,446,251
|
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,446,251
|
||
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
|
||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
4.8%
|
||
12
|
TYPE OF REPORTING PERSON*
IN
|
CUSIP No. 89532E109
|
13G
|
Page 9 of 14 Pages
|
1
|
NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
Augustine Lawlor
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [X]
See Footnote 1
|
||
3
|
SEC USE ONLY
|
||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
||
NUMBER OF
|
5
|
SOLE VOTING POWER
|
|
SHARES
BENEFICIALLY
OWNED BY
|
6
|
SHARED VOTING POWER
2,446,251
|
|
EACH
REPORTING
PERSON
|
7
|
SOLE DISPOSITIVE POWER
|
|
WITH
|
8
|
SHARED DISPOSITIVE POWER
2,446,251
|
|
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,446,251
|
||
10
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
|
||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
4.8%
|
||
12
|
TYPE OF REPORTING PERSON*
IN
|
CUSIP No. 89532E109
|
13G
|
Page 10 of 14 Pages
|
Item 1.
|
(a)
|
Name of Issuer
|
(b)
|
Address of Issuer’s Principal Executive Offices
|
|
1018 West 8th Avenue, Suite A
King of Prussia, PA 19406
|
Item 2.
|
(a) |
Name of Person Filing
|
HealthCare Ventures VIII, L.P. (“HCVVIII”)
HealthCare Partners VIII, L.P. (“HCPVIII”)
HealthCare Partners VIII, LLC (“HCP VIII LLC”)
James H. Cavanaugh, Ph.D. (“Cavanaugh”)
Christopher Mirabelli, Ph.D. (“Mirabelli”)
Harold R. Werner (“Werner”)
John W. Littlechild (“Littlechild”)
Augustine Lawlor (“Lawlor”)
|
|
See attached Exhibit A, which is a copy of their agreement in writing to file this statement on behalf of each of them. 2
|
|
(b) |
Address of Principal Business Office or, if none, Residence
|
The business address for HCVVIII, HCPVIII, HCP VIII LLC, Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild and Lawlor is 47 Thorndike Street, Suite B1-1, Cambridge, Massachusetts 02141.
|
|
(c) |
Citizenship
|
HCVVIII and HCPVIII are limited partnerships organized under the laws of the State of Delaware. HCP VIII LLC is a limited liability company organized under the laws of the State of Delaware. Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild, and Lawlor are each United States citizens.
|
CUSIP No. 89532E109
|
13G
|
Page 11 of 14 Pages
|
(d)
|
Title of Class of Securities
|
|
Common Stock, $0.001 par value per share (the “Common Stock”)
|
(e)
|
CUSIP Number
|
Item 3.
|
If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
|
NOT APPLICABLE.
|
(a)
|
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
|
|
(b)
|
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
|
|
(c)
|
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
|
|
(d)
|
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8).
|
|
(e)
|
An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);
|
|
(f)
|
An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);
|
|
(g)
|
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
|
|
(h)
|
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
|
|
(i)
|
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
|
|
(j)
|
A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);
|
|
(k)
|
Group, in accordance with §240.13d-1(b)(1)(ii)(K).
|
Item 4.
|
Ownership.
|
(a)
|
Amount beneficially owned:
|
|
As of December 31, 2015: Each of HCVVIII, HCPVIII, and HCP VIII LLC, Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild and Lawlor beneficially own 2,446,251 shares of the Issuer’s Common Stock.
|
(b)
|
Percent of class: (based on 50,794,987 shares of the Issuer’s Common Stock issued and outstanding as of December 11, 2015 as reported in the Issuer’s prospectus filed under Rule 424(b)(5), filed with the Securities and Exchange Commission on January 7, 2016).
|
|
As of December 31, 2015: The 2,446,251 shares of the Issuer’s Common Stock beneficially owned by HCVVIII, HCPVIII, HCP VIII LLC, Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild and Lawlor constituted 4.8% of the shares outstanding.
|
CUSIP No. 89532E109
|
13G
|
Page 12 of 14 Pages
|
(c) | Number of shares as to which the person has: | |
(i) | Sole power to vote or to direct the vote – Not Applicable. | |
(ii) |
Shared power to vote or to direct the vote –
|
|
HCVVIII, HCPVIII, HCP VIII LLC, Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild and Lawlor share the power to vote or direct the vote of those shares owned by HCVVIII.
|
||
(iii) |
Sole power to dispose or to direct the disposition of – Not Applicable.
|
|
(iv) |
Shared power to dispose or to direct the disposition of –
|
|
HCVVIII, HCPVIII, HCP VIII LLC, Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild and Lawlor share the power to dispose of or direct the disposition of those shares owned by HCVVIII.
|
Item 5.
|
Ownership of Five Percent or Less of a Class.
|
Item 6.
|
Ownership of More than Five Percent on Behalf of Another Person.
|
Item 7.
|
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.
|
Item 8.
|
Identification and Classification of Members of the Group.
|
Item 9.
|
Notice of Dissolution of Group.
|
Item 10.
|
Certification
|
CUSIP No. 89532E109
|
13G
|
Page 13 of 14 Pages
|
January 29, 2016
|
HealthCare Ventures VIII, L.P.
By: its General Partner, HealthCare Partners VIII, L.P.
By: its General Partner, HealthCare Partners VIII, LLC
/s/ Jeffrey Steinberg
By: _________________________________________
Jeffrey Steinberg, Administrative Officer
|
January 29, 2016
|
HealthCare Partners VIII, L.P.
By: its General Partner, HealthCare Partners VIII, LLC
/s/ Jeffrey Steinberg
By: ________________________________________
Jeffrey Steinberg, Administrative Officer
|
January 29, 2016
|
HealthCare Partners VIII, LLC
/s/Jeffrey Steinberg
By: ________________________________________
Jeffrey Steinberg, Administrative Officer
|
January 29, 2016
|
/s/Jeffery Steinberg, Attorney-in-Fact
James H. Cavanaugh, Ph.D.
|
January 29, 2016
|
/s/Jeffrey Steinberg, Attorney-in-Fact
Christopher Mirabelli, Ph.D.
|
January 29, 2016
|
/s/Jeffrey Steinberg, Attorney-in-Fact
Harold R. Werner
|
January 29, 2016
|
/s/Jeffrey Steinberg, Attorney-in-Fact
John W. Littlechild
|
January 29, 2016
|
/s/Jeffrey Steinberg, Attorney-in-Fact
Augustine Lawlor
|
CUSIP No. 89532E109
|
13G
|
Page 14 of 14 Pages
|
AGREEMENT
|
JOINT FILING OF SCHEDULE 13G
|
January 29, 2016
|
HealthCare Ventures VIII, L.P.
By: its General Partner, HealthCare Partners VIII, L.P.
By: its General Partner, HealthCare Partners VIII, LLC
/s/ Jeffrey Steinberg
By: _________________________________________
Jeffrey Steinberg, Administrative Officer
|
January 29, 2016
|
HealthCare Partners VIII, L.P.
By: its General Partner, HealthCare Partners VIII, LLC
/s/ Jeffrey Steinberg
By: ________________________________________
Jeffrey Steinberg, Administrative Officer
|
January 29, 2016
|
HealthCare Partners VIII, LLC
/s/Jeffrey Steinberg
By: ________________________________________
Jeffrey Steinberg, Administrative Officer
|
January 29, 2016
|
/s/Jeffery Steinberg, Attorney-in-Fact
James H. Cavanaugh, Ph.D.
|
January 29, 2016
|
/s/Jeffrey Steinberg, Attorney-in-Fact
Christopher Mirabelli, Ph.D.
|
January 29, 2016
|
/s/Jeffrey Steinberg, Attorney-in-Fact
Harold R. Werner
|
January 29, 2016
|
/s/Jeffrey Steinberg, Attorney-in-Fact
John W. Littlechild
|
January 29, 2016
|
/s/Jeffrey Steinberg, Attorney-in-Fact
Augustine Lawlor
|