UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                    FORM 8-K

                             CURRENT REPORT Pursuant
                          to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

       Date of report (Date of earliest event reported): November 30, 2004

                            SANGAMO BIOSCIENCES, INC.
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             (Exact Name of Registrant as Specified in Its Charter)

                                    Delaware
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                 (State or Other Jurisdiction of Incorporation)

                000-30171                                 68-0359556
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        (Commission File Number)               (IRS Employer Identification No.)

       501 Canal Blvd, Suite A100                  Richmond, California 94804
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(Address of Principal Executive Offices)                   (Zip Code)

                                 (510) 970-6000
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              (Registrant's Telephone Number, Including Area Code)

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          (Former Name or Former Address, if Changed Since Last Report)

      Check the  appropriate  box below if the Form 8-K  filing is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

      |_| Written  communications  pursuant to Rule 425 under the Securities Act
(17 CFR 230.425)

      |_| Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
CFR 240.14a-12)

      |_|  Pre-commencement  communications  pursuant to Rule 14d-2(b) under the
Exchange Act (17 CFR 240.14d-2(b))

      |_|  Pre-commencement  communications  pursuant to Rule 13e-4(c) under the
Exchange Act (17 CFR 240.13e-4(c))



Item 8.01 Other Events

      On November 30, 2004,  Sangamo  BioSciences  Inc.  issued a press  release
announcing that the company had been granted a United States patent (U.S. Patent
No. 6,824,978) entitled "Regulation of Endogenous Gene Expression in Cells Using
Zinc Finger  Proteins."  The patent  covers the  activation or repression of any
endogenous gene in any cell or organism using engineered zinc finger DNA-binding
proteins (ZFPs) and broadens  Sangamo's  coverage of the uses of engineered ZFPs
to include delivery of ZFP Therapeutics as recombinant proteins.

A copy of the press release issued by Sangamo BioSciences,  Inc. relating to the
issuing of this  patent is filed as an exhibit  to this  Current  Report on Form
8-K.

Item 9.01 Financial Statements and Exhibits

(c)  Exhibits.  The  following  material is filed as an exhibit to this  Current
Report on Form 8-K:

Exhibit No.

99.1     Press Release Issued November 30, 2004.

SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

DATE: November 30, 2004

                                              SANGAMO BIOSCIENCES, INC.

                                          By: /s/ EDWARD O. LANPHIER II
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                                              Edward O. Lanphier II
                                              President, Chief Executive Officer