Charles River and WuXi PharmaTech:
                        The First Global Early-Stage CRO


                                ISS PRESENTATION
                               FOLLOW-UP MATERIALS

 
 

 
 


Safe Harbor Statement

This document includes "forward-looking statements" within the meaning of the
Private Securities Litigation Reform Act of 1995. Forward-looking statements may
be identified by the use of words such as "anticipate," "believe," "expect,"
"estimate," "plan," "outlook," and "project" and other similar expressions that
predict or indicate future events or trends or that are not statements of
historical matters. These statements are based on current expectations and
beliefs of Charles River Laboratories ("Charles River" or "CRL") and WuXi
PharmaTech (Cayman) Inc ("WuXi" or "WX"), and involve a number of risks and
uncertainties that could cause actual results to differ materially from those
stated or implied by the forward-looking statements. Those risks and
uncertainties include, but are not limited to: 1) the possibility that the
proposed combination may be delayed or not completed due to the failure to
obtain stockholder or regulatory approvals or otherwise satisfy the conditions
to the proposed combination as set forth in the acquisition agreement for the
proposed combination; 2) problems may arise in successfully integrating the
businesses of the two companies (including retention of key executives); 3) the
acquisition may involve unexpected costs; 4) the combined company may be unable
to achieve the expected transaction benefits, including improved customer
service levels and anticipated cost and revenue synergies or achieve potential
revenue growth and non-GAAP margin expansion; 5) the businesses may suffer as a
result of uncertainty surrounding the acquisition; and 6) the industry may be
subject to future regulatory or legislative actions and other risks that are
described in Securities and Exchange Commission ("SEC") reports filed or
furnished by Charles River and WuXi. For additional information on these and
other important factors that could adversely affect Charles River's or WuXi's
business, financial condition, results of operations and prospects, see "Risk
Factors" (i) beginning on page 18 of Charles River's Annual Report on Form 10-K
and (ii) beginning on page 6 of WuXi's 2009 Annual Report on Form 20-F, each
filed at the SEC's website www.sec.gov. Forward-looking statements are based on
Charles River's current expectations and beliefs, and involve a number of risks
and uncertainties that are difficult to predict and that could cause actual
results to differ materially from those stated or implied by the forward-looking
statements. Those risks and uncertainties include, but are not limited to: the
ability to successfully integrate the businesses we acquire; the ability to
successfully develop and commercialize SPC's technology platform; a decrease in
research and development spending, a decrease in the level of outsourced
services, or other cost reduction actions by our customers; the ability to
convert backlog to sales; special interest groups; contaminations; industry
trends; new displacement technologies; USDA and FDA regulations; changes in law;
continued availability of products and supplies; loss of key personnel; interest
rate and foreign currency exchange rate fluctuations; changes in tax regulation
and laws; changes in generally accepted accounting principles; and any changes
in business, political, or economic conditions due to the threat of future
terrorist activity in the U.S. and other parts of the world, and related U.S.
military action overseas. A further description of these risks, uncertainties,
and other matters can be found in the Risk Factors detailed in Charles River's
Annual Report on Form 10-K as filed on February 19, 2010 and Quarterly Report on
Form 10-Q as filed on April 29, 2010, as well as other filings we make with the
SEC. Because forward-looking statements involve risks and uncertainties, actual
results and events may differ materially from results and events currently
expected by Charles River and WuXi. Charles River and WuXi assume no obligation
and expressly disclaim any duty to update information contained in this document
except as required by law.



 
 

 
 



Non-GAAP Financial Measures

This presentation includes discussion of non-GAAP financial measures. We believe
that the inclusion of these non-GAAP financial measures provides useful
information to allow investors to gain a meaningful understanding of our core
operating results and future prospects, without the effect of one-time charges,
consistent with the manner in which management measures and forecasts the
Company's performance. The non-GAAP financial measures included in this
presentation are not meant to be considered superior to or a substitute for
results of operations prepared in accordance with GAAP. The company intends to
continue to assess the potential value of reporting non-GAAP results consistent
with applicable rules and regulations.

Additional Information

This document may be deemed to be solicitation material in respect of the
proposed combination of Charles River and WuXi. In connection with the proposed
transaction, Charles River has filed a definitive proxy statement with the SEC.
Before making any voting or investment decisions, stockholders are urged to read
the definitive proxy statement and any other relevant documents filed with the
SEC because they will contain important information. The definitive proxy
statement has been mailed to the stockholders of Charles River seeking their
approval of the proposed transaction. Charles River's stockholders may also
obtain a copy of the definitive proxy statement free of charge by directing a
request to: Charles River Laboratories, 251 Ballardvale Street, Wilmington, MA
01887, Attention: General Counsel. In addition, the definitive proxy statement
is available free of charge at the SEC's website, www.sec.gov or stockholders
may access copies of the documentation filed with the SEC by Charles River on
Charles River's website at www.criver.com/specialwuxi2010.

This document is not a solicitation of proxies from WuXi's shareholders to
approve the proposed combination. In connection with the proposed transaction,
WuXi has filed a scheme document with the SEC on Form 6-K. Before making any
voting or investment decisions, WuXi's shareholders are urged to read the scheme
document and any other relevant documents filed with the SEC because they will
contain important information. The scheme document has been mailed to WuXi's
shareholders seeking their approval of the proposed combination. WuXi's
shareholders may also obtain a copy of the scheme document free of charge by
directing a request to: 288 Fute Zhong Road, Waigaoqiao Free Trade Zone,
Shanghai 200131, People's Republic of China, Attention: Genyong Qiu. In
addition, the scheme document is available free of charge at the SEC's website,
www.sec.gov. WuXi's shareholders may also access copies of the documents filed
with the SEC by WuXi on WuXi's website at www.wuxiapptec.com.

Charles River, WuXi and their respective directors and executive officers and
other members of management may be deemed to be participants in the solicitation
of proxies in respect of the proposed transaction. Information regarding Charles
River's directors and executive officers is available in Charles River's proxy
statement for its 2010 annual meeting of shareholders, which was filed with the
SEC on March 30, 2010. Information regarding the interests of Charles River's
directors and certain members of Charles River's management in the proposed
transaction is set forth in the definitive proxy statement, which was filed with
the SEC on July 1, 2010. Information regarding WuXi's directors and executive
officers is available in WuXi's annual report on Form 20-F for the fiscal year
ended December 31, 2009, which was filed with the SEC on April 23, 2010.
Information regarding the interests of WuXi's directors and certain members of
WuXi's management in the proposed transaction is available in WuXi's scheme
document, which was filed on Form 6-K with the SEC on July 1, 2010.

This document does not constitute an offer of any securities for sale or a
solicitation of an offer to buy any securities. The Charles River shares to be
issued in the proposed transaction have not been and will not be registered
under the Securities Act of 1933, as amended (the "Securities Act"), and may not
be offered or sold in the United States absent registration or an applicable
exemption from registration requirements. Charles River intends to issue such
Charles River shares pursuant to the exemption from registration set forth in
Section 3(a)(10) of the Securities Act.

 
 

 
 


The Value of Synergies is Greater than the Premium Paid for WuXi

Note: All values rounded to nearest $5mm

(1)  Based on 28% premium paid on WuXi share price of $16.57 as of 4/23/10

(2)  Based on midpoint of J.P. Morgan standalone DCF for WuXi in section
     entitled "Opinion of Charles River's Financial Advisor" beginning on page
     45 of CRL definitive proxy statement filed 7/1/10

(3)  Based on midpoint of Credit Suisse standalone DCF for WuXi in section
     entitled "Opinion of Financial Advisor to WuXi" beginning on page 35 of WX
     scheme document filed 7/1/10

(4)  Value of cost synergies based on a 10.5x FV / EBITDA multiple
     (pre-announcement blended FV / EBITDA multiple weighted based on firm value
     contribution) applied to $20mm of cost synergies

(5)  Value of revenue synergies based on a 10.5x FV / EBITDA multiple applied to
     $75mm to $100mm of run-rate revenue synergies at a 25% to 30% margin



 
 

 
 



The Purchase Price is Attractive on a PEG Ratio Basis

Note: Current purchase price as of 7/16/10 assuming CRL stock price of $34.12,
exchange ratio at high end of collar (0.2688x), and 75.5 fully-diluted WX shares
outstanding

(1)  ______ WX non-GAAP EPS based on Wall Street research average as of 4/23/10
     and adjusted to include stock compensation expense of $10.6mm (per Wall
     Street research). CRL non-GAAP EPS based on I/B/E/S consensus estimates as
     of 4/23/10

(2)  ______ Includes pre-tax cost synergies of $20mm as disclosed in CRL
     definitive proxy, taxed at 25.5%. Profit contribution from 1/3 of $87.5mm
     run-rate revenue synergies (midpoint of $75mm to $100mm range) assumed to
     be 27.5% (midpoint of 25% to 30% range) taxed at 25.5%



 
 

 
 



Proposed Transaction with WuXi Will Significantly Improve Charles River's
Revenue Growth and Margins

(1)  Based on WuXi unaudited prospective financial information of revenue and
     adjusted non-GAAP operating income as disclosed on page 53 of CRL
     definitive proxy filed 7/1/10, less estimated stock compensation expense of
     $13mm

(2)  Based on 2/3 of $87.5mm of run-rate revenue synergies (midpoint of $75mm to
     $100mm range)

(3)  2009 revenue includes WuXi 2009A revenue of $270mm for CAGR calculation

(4)  Based on $20mm of cost synergies as disclosed in CRL definitive proxy filed
     7/1/10, growing in line with forecasted cost structure beginning in 2011

(5)  Based on 27.5% contribution (midpoint of 25% to 30% range) on $58mm of
     revenue synergies shown above


 
 

 
 



The Transaction Adds Meaningfully to CRL's Standalone Long-Term Earnings Growth

(1)  Scenarios assume CRL revenues and EPS grow at 0%, 5% and 10% annual rate,
     respectively, from 2009A levels; EBITDA and EBITA margins constant at 2009
     levels; capex and net working capital forecast at 2009 percentage of sales

(2)  Assumes CRL stock price of $34.12 as of 7/16/10, exchange ratio of .2688x,
     75.5mm WuXi diluted shares outstanding, blended tax rate of 25.5%; WX
     through 2012 based on unaudited prospective financial information as
     disclosed in CRL definitive proxy statement filed 7/1/10 less estimated
     annual stock compensation expense; WX subsequently grown at I/B/E/S mean
     long-term growth rate of 17.2%; includes $20mm of cost synergies beginning
     in 2011 growing in line with forecasted cost structure taxed at 25.5%;
     includes annual revenue synergies of $87.5mm phased in over three years
     beginning in 2011 growing in line with forecasted revenue growth beginning
     in 2014 taxed at 25.5%

(3)  Stock repurchases occur at beginning of year starting in 2011; prior year's
     free cash flow and new borrowing up to 3.0x total debt / LTM EBITDA used
     for repurchases; net working capital assumed to be 16.5% of revenue (based
     on 2009 percentage of revenue); assumes shares are repurchased during 2011
     at 5.0% premium to $39.77 share price as of 4/23/10; thereafter shares are
     repurchased at 17.5x PF LTM EPS (2010 P/E multiple assuming unaffected CRL
     stock price of $39.77 as of 04/23/10 and 2010 I/B/E/S mean EPS of $2.27 as
     of 4/23/10) plus 5.0% premium; assumes tax rate of 29.0%, interest income
     rate of 2.0% and cost of debt of 4.5%


(4)  Stock repurchases occur at beginning of year starting in 2011; prior year's
     free cash flow and new borrowing up to 3.0x total debt / LTM EBITDA used
     for repurchases; net working capital assumed to be 16.5% of PF revenue
     (based on 2009 percentage of revenue); assumes 2011 shares are repurchased
     at 5.0% premium to $39.77 share price as of 4/23/10; thereafter shares are
     repurchased at 17.5x PF LTM EPS (2010 P/E multiple assuming unaffected CRL
     stock price of $39.77 as of 04/23/10 and 2010 I/B/E/S mean EPS of $2.27 as
     of 4/23/10) plus 5.0% premium; assumes blended tax rate of 25.5%, interest
     income rate of 2.0% and cost of debt of 4.5%