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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549
                           --------------------------

                                    FORM 8-K

                                 CURRENT REPORT
                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

       Date of report (Date of earliest event reported): October 15, 2006

                             ORION HEALTHCORP, INC.
             (Exact Name of Registrant as Specified in its Charter)

        Delaware                   001-16587                   58-1597246
    (State or Other             (Commission File            (I.R.S. Employer
    Jurisdiction of                  Number)                  Identification
     Incorporation)                                              Number)

                        1805 Old Alabama Road, Suite 350
                                Roswell, GA 30076
               (Address of Principal Executive Offices) (Zip Code)

                                 (678) 832-1800
              (Registrant's Telephone Number, Including Area Code)

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_|  Written communications pursuant to Rule 425 under the Securities Act (17
     CFR 230.425)

|_|  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

|_|  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))

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Section 1 Registrant's Business and Operations

Item 1.01 Entry into a Material Definitive Agreement

          On March 16, 2005,  Brantley Partners IV, L.P.  ("Brantley IV") loaned
          Orion HealthCorp, Inc. (the "Company") an aggregate of $1,025,000 (the
          "First  Loan").  On June 1, 2005,  the Company  executed a convertible
          subordinated  promissory  note in the  principal  amount of $1,025,000
          (the "First Note") payable to Brantley IV to evidence the terms of the
          First Loan. The material  terms of the First Note are as follows:  (i)
          the First Note is unsecured; (ii) the First Note is subordinate to the
          Company's outstanding loan from CIT Healthcare,  LLC ("CIT") and other
          indebtedness  for monies  borrowed,  and ranks pari passu with general
          unsecured trade liabilities; (iii) principal and interest on the First
          Note is due in a lump sum on April 19, 2006 (the "First Note  Maturity
          Date");  (iv) the  interest on the First Note  accrues  from and after
          March 16, 2005,  at a per annum rate equal to nine percent  (9.0%) and
          is  non-compounding;  (v)  if  an  event  of  default  occurs  and  is
          continuing,  Brantley  IV, by notice to the  Company,  may declare the
          principal  of the First Note to be due and  immediately  payable;  and
          (vi) on or after the First Note  Maturity  Date,  Brantley  IV, at its
          option, may convert all or a portion of the outstanding  principal and
          interest  due of the First Note into shares of Class A Common Stock of
          the Company at a price per share equal to  $1.042825  (the "First Note
          Conversion Price"). The number of shares of Class A Common Stock to be
          issued upon  conversion of the First Note shall be equal to the number
          obtained  by  dividing  (x) the  aggregate  amount  of  principal  and
          interest to be  converted by (y) the First Note  Conversion  Price (as
          defined above);  provided,  however, the number of shares to be issued
          upon  conversion of the First Note shall not exceed the lesser of: (i)
          1,159,830  shares of Class A Common  Stock,  or (ii) 16.3% of the then
          outstanding  Class A Common Stock. As of October 15, 2006, if Brantley
          IV were to convert  the First Note,  the  Company  would have to issue
          1,124,937 shares of Class A Common Stock. On May 9, 2006,  Brantley IV
          and the Company  executed an  amendment  to the First Note (the "First
          and Second Note Amendment")  extending the First Note Maturity Date to
          August  15,  2006.  On August 8,  2006,  Brantley  IV and the  Company
          executed a second  amendment  to the First Note (the "First and Second
          Note Second  Amendment")  extending  the First Note  Maturity  Date to
          October 15, 2006.

          On October 15,  2006,  Brantley  IV and the Company  executed a second
          amendment  to the  First  Note  (the  "First  and  Second  Note  Third
          Amendment")  extending  the First Note  Maturity  Date to November 30,
          2006. A copy of the First and Second Note Third  Amendment is attached
          hereto as Exhibit 10.1.

          On April 19,  2005,  Brantley  IV loaned  the  Company  an  additional
          $225,000 (the "Second Loan").  On June 1, 2005, the Company executed a
          convertible  subordinated  promissory note in the principal  amount of
          $225,000  (the "Second  Note")  payable to Brantley IV to evidence the
          terms of the Second Loan. The material terms of the Second Note are as
          follows:  (i) the Second  Note is  unsecured;  (ii) the Second Note is
          subordinate  to the  Company's  outstanding  loan  from CIT and  other
          indebtedness  for monies  borrowed,  and ranks pari passu with general
          unsecured  trade  liabilities;  (iii)  principal  and  interest on the
          Second Note is due in a lump sum on April 19, 2006 (the  "Second  Note
          Maturity Date"); (iv) the interest on the Second Note accrues from and
          after April 19, 2005, at a per annum rate equal to nine percent (9.0%)
          and is  non-compounding;  (v) if an event  of  default  occurs  and is
          continuing,  Brantley  IV, by notice to the  Company,  may declare the
          principal of the Second Note to be due and  immediately  payable;  and
          (vi) on or after the Second Note  Maturity  Date,  Brantley IV, at its
          option, may convert all or a portion of the outstanding  principal and
          interest due of the Second Note into shares of Class A Common Stock of
          the Company at a price per share equal to $1.042825  (the "Second Note
          Conversion Price"). The number of shares of Class A Common Stock to be
          issued upon conversion of the Second Note shall be equal to the number
          obtained  by  dividing  (x) the  aggregate  amount  of  principal  and
          interest to be converted by (y) the Second Note  Conversion  Price (as
          defined above);  provided,  however, the number of shares to be issued
          upon conversion of the Second Note shall not exceed the lesser of: (i)
          254,597  shares  of Class A  Common  Stock,  or (ii)  3.6% of the then
          outstanding  Class A Common Stock. As of October 15, 2006, if Brantley
          IV were to convert the Second  Note,  the Company  would have to issue
          245,103  shares of Class A Common Stock.  On May 9, 2006,  Brantley IV
          and the Company executed the First and Second Note Amendment extending
          the Second Note  Maturity  Date to August 15, 2006. On August 8, 2006,
          Brantley IV and the Company  executed the First and Second Note Second
          Amendment extending the Second Note Maturity Date to October 15, 2006.




          On October 15,  2006,  Brantley IV and the Company  executed the First
          and Second Note Third  Amendment  extending  the Second Note  Maturity
          Date to November 30, 2006.

Section 9 Financial Statements and Exhibits

Item 9.01 Financial Statements and Exhibits

(d) Exhibits - The following exhibits are furnished as part of this current
report:

Exhibit   Description
-------   -----------
10.1      Third Amendment to Convertible Subordinated Promissory Notes, dated as
          of October 15, 2006, by and between Orion HealthCorp, Inc. and
          Brantley Partners IV, L.P.




                                   SIGNATURES
                                   ----------

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Company has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                                 ORION HEALTHCORP, INC.


                                                 By: /s/ Stephen H. Murdock
                                                     ----------------------
                                                     Stephen H. Murdock
                                                     Chief Financial Officer



Date: October 19, 2006




                                  EXHIBIT INDEX

Exhibit
Number    Description of Exhibits
------    -----------------------

10.1      Third Amendment to Convertible Subordinated Promissory Notes, dated as
          of October 15, 2006, by and between Orion HealthCorp, Inc. and
          Brantley Partners IV, L.P.