PAGE  1
000 A000000 09/30/2012
000 C000000 0001350869
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 CLOUGH GLOBAL OPPORTUNITIES FUND
001 B000000 811-21846
001 C000000 8772568445
002 A000000 1290 BROADWAY, SUITE 1100
002 B000000 DENVER
002 C000000 CO
002 D010000 80203
003  000000 N
004  000000 N
005  000000 N
006  000000 N
007 A000000 N
007 B000000  0
008 A000001 CLOUGH CAPITAL PARTNERS
008 B000001 A
008 C000001 801-63142
008 D010001 BOSTON
008 D020001 MA
008 D030001 02109
010 A000001 ALPS FUND SERVICES, INC.
010 B000001 84-5730
010 C010001 DENVER
010 C020001 CO
010 C030001 80203
011 A000001 MERRILL LYNCH
011 B000001 8-0114235
011 C010001 NEW YORK
011 C020001 NY
011 C030001 10080
012 A000001 COMPUTERSHARE SHAREOWNER SERVICES LLC
012 B000001 84-05579
012 C010001 JERSEY CITY
012 C020001 NJ
012 C030001 07310
013 A000001 COHEN FUND AUDIT SERVICES, LTD.
013 B010001 WESTLAKE
013 B020001 OH
013 B030001 44145
015 A000001 BANK OF NEW YORK MELLON
015 B000001 C
015 C010001 NEW YORK
015 C020001 NY
      PAGE  2
015 C030001 10286
015 E010001 X
015 A000002 HSBC Bank Malaysia
015 B000002 S
015 C010002 Kuala Lumpur
015 D010002 Malaysia Berhad
015 D020002 206-001
015 E040002 X
015 A000003 Clearstream Banking Frankfurt
015 B000003 S
015 C010003 Frankfurt
015 D010003 Germany
015 D020003 7297
015 E040003 X
015 A000004 CICB Mellon Trust Company
015 B000004 S
015 C010004 Toronto
015 D010004 Canada
015 D020004 M5H 4A6
015 E040004 X
015 A000005 DBS Bank Ltd., Singapore
015 B000005 S
015 C010005 The Comtech
015 D010005 Singapore
015 D020005 118502
015 E040005 X
015 A000006 HSBC Bank Hong Kong
015 B000006 S
015 C010006 Kowloon
015 D010006 Hong Kong
015 D020006 C00019
015 E040006 X
015 A000007 HSBC Seoul
015 B000007 S
015 C010007 Bongrae-dong
015 D010007 South Korea
015 D020007 1-ga Seoul
015 E040007 X
015 A000008 HSBC Manila
015 B000008 C
015 C010008 Taguig City
015 D010008 Philippines
015 D020008 1634
015 E030008 X
015 A000009 Citibank N.A., Brazilian Branch
015 B000009 S
015 C010009 Sao Paulo
015 D010009 Brazil
015 D020009 01311
015 E040009 X
018  000000 Y
      PAGE  3
019 A000000 N
019 B000000    0
020 A000001 KNIGHT EQUITY MARKETS, LP
020 B000001 22-3660471
020 C000001     257
020 A000002 MERRILL LYNCH & CO., INC.
020 B000002 13-2740599
020 C000002     144
020 A000003 SUSQUEHANNA FINANCIAL GROUP LLLP
020 B000003 23-2626048
020 C000003     131
020 A000004 STATE STREET GLOBAL MARKETS, LLC
020 B000004 04-3464336
020 C000004     127
020 A000005 CREDIT SUISSE SECURITIES (USA) LLC
020 B000005 05-0546650
020 C000005      97
020 A000006 BARCLAYS CAPITAL, INC.
020 B000006 06-1031656
020 C000006      75
020 A000007 UBS FINANCIAL SERVICES, INC.
020 B000007 13-2638166
020 C000007      69
020 A000008 GOLDMAN SACHS & CO.
020 B000008 13-5108880
020 C000008      62
020 A000009 BNP PARIBAS SECURITIES CORP.
020 B000009 13-3459854
020 C000009      60
020 A000010 BNY CONVERGEX EXECUTION SOLUTIONS LLC
020 B000010 13-3989198
020 C000010      59
021  000000      1737
022 A000001 DREYFUS TREASURY PRIME CASH MANAGEMENT
022 C000001     380133
022 D000001     416449
022 A000002 LEGG MASON WOOD WALKER, INC.
022 B000002 52-0902557
022 C000002     100087
022 D000002     132469
022 A000003 RAYMOND JAMES & ASSOCIATES, INC.
022 B000003 59-1237041
022 C000003      59510
022 D000003      50004
022 A000004 MORGAN STANLEY & CO., INC.
022 B000004 13-2655998
022 C000004      81623
022 D000004      23526
022 A000005 CREDIT SUISSE SECURITIES (USA) LLC
022 B000005 05-0546650
022 C000005      26257
      PAGE  4
022 D000005      23347
022 A000006 STIFEL, NICOLAUS & CO., INC.
022 B000006 43-0538770
022 C000006      24143
022 D000006      24110
022 A000007 MORGAN STANLEY INTITUTIONAL LIQUIDITY FUND
022 C000007       9910
022 D000007       9910
022 A000008 BARCLAYS CAPITAL, INC.
022 B000008 06-1031656
022 C000008      15628
022 D000008          0
022 A000009 ITAU BBA USA SECURITIES, INC.
022 B000009 13-4197122
022 C000009       5306
022 D000009          0
022 A000010 JP MORGAN CHASE & CO.
022 B000010 13-2624428
022 C000010       4699
022 D000010          0
023 C000000      714223
023 D000000      681672
024  000000 Y
025 A000001 GOLDMAN SACHS & CO.
025 B000001 13-5108880
025 C000001 E
025 D000001     3929
025 A000002 JP MORGAN CHASE & CO.
025 B000002 13-2624428
025 C000002 E
025 D000002     2421
025 A000003 DREYFUS TREASURY PRIME CASH MANAGEMENT
025 B000003 -
025 C000003 D
025 D000003    32916
025 A000004 BANK OF AMERICA NA
025 B000004 94-1687665
025 C000004 E
025 D000004    26706
025 A000005 CITIGROUP GLOBAL MARKETS, INC.
025 B000005 11-2418191
025 C000005 E
025 D000005    23798
026 A000000 N
026 B000000 Y
026 C000000 Y
026 D000000 Y
026 E000000 Y
026 F000000 N
026 G010000 N
026 G020000 N
      PAGE  5
026 H000000 N
027  000000 N
045  000000 Y
046  000000 N
047  000000 Y
048  000000  1.000
048 A010000         0
048 A020000 0.000
048 B010000         0
048 B020000 0.000
048 C010000         0
048 C020000 0.000
048 D010000         0
048 D020000 0.000
048 E010000         0
048 E020000 0.000
048 F010000         0
048 F020000 0.000
048 G010000         0
048 G020000 0.000
048 H010000         0
048 H020000 0.000
048 I010000         0
048 I020000 0.000
048 J010000         0
048 J020000 0.000
048 K010000         0
048 K020000 0.000
049  000000 N
050  000000 N
051  000000 N
052  000000 N
053 A000000 N
054 A000000 Y
054 B000000 Y
054 C000000 Y
054 D000000 Y
054 E000000 Y
054 F000000 N
054 G000000 Y
054 H000000 Y
054 I000000 N
054 J000000 Y
054 K000000 Y
054 L000000 N
054 M000000 Y
054 N000000 N
054 O000000 Y
055 A000000 N
055 B000000 Y
056  000000 Y
      PAGE  6
057  000000 N
058 A000000 N
059  000000 Y
060 A000000 N
060 B000000 N
061  000000         0
062 A000000 N
062 B000000   0.0
062 C000000   0.0
062 D000000   0.0
062 E000000   0.0
062 F000000   0.0
062 G000000   0.0
062 H000000   0.0
062 I000000   0.0
062 J000000   0.0
062 K000000   0.0
062 L000000   0.0
062 M000000   0.0
062 N000000   0.0
062 O000000   0.0
062 P000000   0.0
062 Q000000   0.0
062 R000000   0.0
066 A000000 Y
066 B000000 N
066 C000000 N
066 D000000 N
066 E000000 N
066 F000000 N
066 G000000 Y
067  000000 Y
068 A000000 N
068 B000000 N
069  000000 N
070 A010000 Y
070 A020000 N
070 B010000 Y
070 B020000 Y
070 C010000 Y
070 C020000 N
070 D010000 Y
070 D020000 N
070 E010000 Y
070 E020000 N
070 F010000 Y
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 Y
070 H020000 N
      PAGE  7
070 I010000 N
070 I020000 N
070 J010000 Y
070 J020000 N
070 K010000 Y
070 K020000 Y
070 L010000 Y
070 L020000 Y
070 M010000 Y
070 M020000 Y
070 N010000 Y
070 N020000 Y
070 O010000 Y
070 O020000 Y
070 P010000 N
070 P020000 N
070 Q010000 N
070 Q020000 N
070 R010000 Y
070 R020000 Y
071 A000000     959267
071 B000000     956799
071 C000000     918946
071 D000000  104
072 A000000  6
072 B000000      1458
072 C000000     11529
072 D000000         0
072 E000000       216
072 F000000      6405
072 G000000      2050
072 H000000         0
072 I000000         0
072 J000000         0
072 K000000         0
072 L000000         0
072 M000000        68
072 N000000         0
072 O000000         0
072 P000000      3696
072 Q000000         0
072 R000000         0
072 S000000        11
072 T000000         0
072 U000000         0
072 V000000         0
072 W000000      2027
072 X000000     14257
072 Y000000         0
072 Z000000     -1054
072AA000000      1881
      PAGE  8
072BB000000         0
072CC010000         0
072CC020000      5588
072DD010000     27938
072DD020000         0
072EE000000         0
073 A010000    0.5400
073 A020000    0.0000
073 B000000    0.0000
073 C000000    0.0000
074 A000000       404
074 B000000         0
074 C000000     88096
074 D000000    131374
074 E000000      2995
074 F000000    804839
074 G000000      1121
074 H000000         0
074 I000000     16364
074 J000000     51738
074 K000000         0
074 L000000      3075
074 M000000    212540
074 N000000   1312546
074 O000000     21433
074 P000000      1398
074 Q000000         0
074 R010000         0
074 R020000    216838
074 R030000       294
074 R040000    389070
074 S000000         0
074 T000000    683513
074 U010000     51737
074 U020000         0
074 V010000     13.21
074 V020000      0.00
074 W000000    0.0000
074 X000000        18
074 Y000000    840704
075 A000000         0
075 B000000    674121
076  000000     11.70
077 A000000 N
078  000000 N
080 C000000         0
081 B000000    0
086 A010000       0
086 A020000       0
086 B010000       0
086 B020000       0
      PAGE  9
086 C010000       0
086 C020000       0
086 D010000       0
086 D020000       0
086 E010000       0
086 E020000       0
086 F010000       0
086 F020000       0
087 A010000 COMMON STOCK
087 A020000 18914E106
087 A030000 GLO
088 A000000 Y
088 B000000 N
088 C000000 N
088 D000000 N
SIGNATURE   Dawn Cotten
TITLE       Assistant Treasurer