Two poster presentations at AAIC provide early evidence of the value of ultra-low-field Swoop® system MR brain images in ARIA-E detection and morphography evaluation in patients with Alzheimer's disease

Hyperfine, Inc. (Nasdaq: HYPR), the groundbreaking health technology company that has redefined brain imaging with the first FDA-cleared portable magnetic resonance (MR) brain imaging system—the Swoop® system—today announced the presentation of data using the Swoop system to image patients with Alzheimer’s disease including initial data from the CARE PMR study. The data was presented at the 2024 Alzheimer’s Association International Conference (AAIC) in Philadelphia from July 28 to August 1.

The CARE PMR (Capturing ARIA Risk Equitably with Portable MR) study is a collection of data from multiple sites assessing the clinical utility and workflow benefits of using Swoop® system images to detect amyloid-related imaging abnormalities (ARIA) in Alzheimer’s patients receiving amyloid-targeting therapy. These investigator-initiated observational studies aim to provide insights into the potential of ultra-low-field, portable MR brain imaging to enhance care for patients with Alzheimer's disease across many sites of care.

At the conference, researchers from Washington University in St. Louis, a center actively enrolling patients in the CARE PMR study, presented a poster titled "Advanced Imaging Modalities for ARIA Detection and Treatment Efficacy Monitoring in Lecanemab Therapy for Alzheimer's Disease: A Collaborative Prospective Study." The poster, authored by Jude-Patrick Nnamdi Okafor, MD, et al., reported data on sixteen patients. Notably, one participant exhibited "evidence of hyperintensity on FLAIR, consistent with ARIA-E,” which was deemed “well detected at low field strength.”

Researchers from Massachusetts General Hospital virtually presented a poster titled "Portable, Low-field MRI for Alzheimer’s Disease," authored by W. Taylor Kimberly, MD, PhD, et al. This poster focused on the quantitative assessment of ultra-low-field MRI images compared to conventional high-field MR images in evaluating brain morphometry in Alzheimer's patients. The study highlighted a strong agreement in volumes between conventional high-field MR images and low-field MR images. The poster concluded, “Given its portability and low operational cost, [low-field] MRI holds promise as a valuable tool to diagnose [Alzheimer's disease] and monitor its progression.”

Dr. Edmond Knopp, Vice President of Medical Affairs at Hyperfine, commented, “The impressive image quality achieved with our ultra-low-field MRI technology opens up the potential to provide critical diagnostic information for patients with Alzheimer's disease across many sites of care, including infusion centers and clinics that currently cannot offer on-site imaging capabilities. These posters provide early evidence that portable MRI could transform Alzheimer's disease management.”

Access the abstracts through AAIC using the following links:

Title: Advanced Imaging Modalities for ARIA Detection and Treatment Efficacy Monitoring in Lecanemab Therapy for Alzheimer's Disease: A Collaborative Prospective Study

Authors: Jude-Patrick Nnamdi Okafor, MD, et al.

Title: Portable, Low-field MRI for Alzheimer’s Disease

Authors: W. Taylor Kimberly MD PhD, et al.

For more information about the Swoop® Portable MR Imaging® system, please visit hyperfine.io.

About the Swoop® Portable MR Imaging® System

The Swoop® Portable MR Imaging® system is U.S. Food and Drug Administration (FDA) cleared for brain imaging of patients of all ages. It is a portable, ultra-low-field magnetic resonance imaging device for producing images that display the internal structure of the head where full diagnostic examination is not clinically practical. When interpreted by a trained physician, these images provide information that can be useful in determining a diagnosis. The Swoop® system also has CE certification in the European Union and UKCA certification in the United Kingdom. The Swoop® system is commercially available in a select number of international markets.

About Hyperfine, Inc.

Hyperfine, Inc. (Nasdaq: HYPR) is the groundbreaking health technology company that has redefined brain imaging with the Swoop® system—the first FDA-cleared, portable, ultra-low-field, magnetic resonance brain imaging system capable of providing imaging at multiple points of care. The mission of Hyperfine, Inc. is to revolutionize patient care globally through transformational, accessible, clinically relevant diagnostic imaging. Founded by Dr. Jonathan Rothberg in a technology-based incubator called 4Catalyzer, Hyperfine, Inc. scientists, engineers, and physicists developed the Swoop® system out of a passion for redefining brain imaging methodology and how clinicians can apply accessible diagnostic imaging to patient care. For more information, visit hyperfine.io.

Hyperfine, Swoop, and Portable MR Imaging are registered trademarks of Hyperfine, Inc.

Forward-Looking Statements

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